Boyne MS, Silver DM, Kaplan J, Saudek CD (2003) Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor. Diabetes 52(11):2790–2794 Xiao YF, Wang B, Wang X, Du F, Benzinou M, Wang YX (2013) Xylazine-induced reduction of tissue sensitivity to insulin leads to acute hyperglycemia in diabetic and normoglycemic monkeys. BMC Anesthesiol 13(1):33 There are six tie-down points total: two on the top, two on the upper platform, and two on the base. Islam MS (2013) Animal models of diabetic neuropathy: progress since 1960s. J Diabetes Res. doi: 10.1155/2013/149452

The survey identified large variation in the types of chair used, the methods of transferring the monkey from the home environment into the chair, the time allowed to prepare the animals for chair restraint equipment before research procedures begin, and the roles of the personnel involved.

Where Can I Get More Bondage Gear to Build a Dungeon?

That’s where inflatable toys like Dark Magic come in. It inflates into this lounger (a foot pump is provided to blow it up) which holds the thrusting motor exactly where you need it. There are bolsters built in to prop your legs up and there is space on either side of these bolsters for your legs if you want to flip over on your knees. To make it extra spicy, there’s a slot in the center of the seat where you can put an insertable toy and then sit your sub right down on it and hold them there with the restraints. The chair comes with a toy to start with that fits the slot but be warned that it’s quite realistic if that’s not your general toy preference. This Spanking Bench is made right here in the USA using real hardwood and metal, so if you’re looking for a substantial piece that you can trust to be sturdy, this is for you. There are cheaper versions of this type of chair but this is a solid, quality product for something you really don’t want failing on you in the middle of your night.

Specifically-designed restraint chairs are commonly used in research studies that require non-human primates to ‘sit’ in place for sustained periods of time (e.g. behavioural neuroscience and drug infusion studies). Despite widespread use of restraint chairs, there is little published information about the methods used to train monkeys to accept this form of restraint, which can be a stressful procedure for these animals.The Dark Magic Inflatable Thrusting Machine looks like it could be a simple inflatable lounger with really good leg support–that is until you notice the remote control that controls motor thrusting toys for a realistic experience while you’re going solo.

Furniture that is designed with getting down in mind is fantastic for people who find themselves frustrated, uncomfortable, or in pain with certain positions. This includes partnerships with a wide difference in body type or height and everyone as we age. It comes with two different silicone attachments, one with internal stimulation and one without so there’s a little something for everyone. It has 10 vibration functions as well as many levels of intensity. I love that the Cowgirl is app-enabled so it can be controlled using a smartphone from up to 30 feet away. If you’re playing with your partner they can take the reins of your toy across the house. There’s also a wired remote for ease of adjustment with a 10-foot cord. ITT is used to examine if the body produces enough ACTH (adreno-cortico-trophic hormone) and growth hormone under stress. The ‘stress’ in this test was to lower blood sugar (hypoglycemia) by injected insulin under very controlled conditions. ACTH stimulates the adrenal glands to make cortisol which is a steroid hormone and has many functions, including balancing the effect of insulin in regulating blood glucose levels. Five animals (normoglycemia, n = 3 and diabetes, n = 2) were fasted overnight (16 h) and restrained in the monkey chair. When blood glucose levels stabilized for around 30 min via observation of the HD-XG glucose signals, the insulin solution (0.15 U/kg = 0.15 mL/kg of insulin injection) was given to each animal via S.C. injection [ 5]. Blood glucose levels were measured by the glucometer method (StatStrip Xpress meter) immediately before and at 30, 60, 90, and 120 min after insulin administration (Fig. 7, ITT). Meanwhile, blood glucose levels were monitored and recorded by implanted HD-XG devices. The results were plotted against the time and were correlated very well between the telemetry results and the glucometer readings. GGI The monkeys housed in our animal facility were fed twice per day. The postprandial increase in blood glucose was very minor with a few small fluctuations after morning feeding and was more obvious with one main peak after afternoon feeding (Fig. 4a). This pattern of food intake in NHPs differs from humans. Generally speaking, humans complete their meals in a certain period of time (most likely less than 1 h). Blood glucose increase after a meal is more obvious and relatively predictable in humans. However, most of our housed monkeys might not complete their meals in a relatively short period of time, especially after morning feeding. The monkeys could eat and play with their food for quite a while, which initiated those small fluctuations of blood glucose after morning feeding (Fig. 4a). Postprandial increase in blood glucose was more obvious with one main peak after afternoon feeding. This peak potentially indicated the change of the housed monkey behavior. They were smart to intake enough food before 7 pm as the access became difficult after light off. This postprandial blood glucose pattern in housed NHPs also resulted from the advantage of the implantable telemetry device which did not affect animal normal behavior. Ensuring that the chair restraint process is as fully refined as possible will reduce any stress and discomfort to a minimum, facilitating good performance from the monkey and good scientific data. Workshop fundingPositioning furniture can help take the strain off of your body and enable you to try positions you might not be able to otherwise. That could be something as simple as a cushion to support your spine and reduce your pain or something more involved like a sex bench to hold limbs in place. Hansen BC (2012) Investigation and treatment of type 2 diabetes in nonhuman primates. Methods Mol Biol 933:177–185 Helton KL, Ratner BD, Wisniewski NA (2011) Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and foreign body response-part II: examples and application. Journal of diabetes science technology 5(3):647–656

The survey aimed to obtain an overview of current practice, including the equipment and methods used for preparing monkeys for chair restraint procedures, the challenges involved, and plans for improvement. Responses were received from 101 laboratories in the academic, government, contract research and pharmaceutical industry sectors in the Americas (62), Europe (33) and Asia (6). DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237(3):E214–E223 Chatzigeorgiou A, Halapas A, Kalafatakis K, Kamper E (2009) The use of animal models in the study of diabetes mellitus. In Vivo 23(2):245–258 Blood glucose, body temperature and physical activities were continuously and simultaneously recorded by implanted HD-XG telemetry device for up to 10 weeks. Results and discussion

Sasase T, Pezzolesi MG, Yokoi N, Yamada T, Matsumoto K (2013) Animal models of diabetes and metabolic disease. J Diabetes Res. doi: 10.1155/2013/281928 Ensuring that the chair restraint process is as fully refined as possible will reduce any stress and discomfort to a minimum, ultimately facilitating good performance from the monkey and good quality scientific data. The authors conclude that there is a need for members of the non-human primate research community to work together to refine chair restraint procedures, and provide a number of recommendations for refinement. These include more pre-study training based on positive reinforcement techniques, standard operating procedures to increase consistency in animal training and monitoring, greater use of specialist training consultants and discussion of training procedures between laboratories, and the need for staff to have a better understanding of macaque behaviour. It also has a hole on top of it where you can insert a vibe or other toy and you can use it as a mountable chair or stand it up on its side flat against the headboard. The overnight-fasted monkeys were restrained in the monkey chair. After stabilization of their blood glucose levels based on the HD-XG glucose signals, angiotensin II at 2 μg/kg was administered intravenously by bolus injection. Blood glucose level gradually increased and reached the peak within 10 min after angiotensin II injection in both normoglycemic (L02) and diabetic (J04) monkeys (Fig. 6b). The hyperglycemic response to angiotensin II slowly waned and lately even went lower than the pre-angiotensin II level in the diabetic animal (J04, Fig. 6b). It is interesting that intravenous bolus injection of acetylcholine at 1 μg/kg did not alter blood glucose levels in both normoglycemic and diabetic monkeys implanted with HD-XG telemetry devices (data not shown). Glucose tolerance test and other tests in NHPs with implanted HD-XG device Wang B, Sun G, Liu Y, Qiao J, Ye W, Wang H, Wang X, Chng K, Qiao W, Wang Y et al (2016) Dysglycemia and dyslipidemia models in nonhuman primates: part II. Model of naturally occurring or experimental obesity. J Diabetes Metab 6:641. doi: 10.4172/2155-6156.1000641