Holloway GA, Johansen KH, Barnes RW, Pierce GE. Multicenter Trial of Cadexomer Iodine to Treat Venous Stasis Ulcer. The Western Journal of Medicine. 1989;151(1):35-38. Smith & Nephew 2018.Antimicrobial activity of IODOSORB range in a 3 day repeat challenge model. Internal Report. 1801002. Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of topical iodine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. Interactions with Medicines Known or suspected hypersensitivity to iodine. IODOSORB should not be used by persons who are allergic to iodine. Cadexomer iodine should not be used on patients with Hasimoto’s thyroiditis, thyroid disease, patients with a prior history of Grave’s disease and non-toxic nodular goitre, or on children or neonates. IODOSORB should not be used during pregnancy or by breastfeeding females. Drug interactions

Cover with an appropriate secondary dressing e.g. Melolin or Allevyn. Apply compression bandaging where appropriate.Hesler B. Release of iodine from IODOSORB Powder into 0.9% saline solution over a three day period. Smith&Nephew Data on File # DS.18.024.R. (2018).

Woo K, Dowsett C, Costa B, Ebohon S, Woodmansey EJ, Malone M. Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta-analysis of comparative clinical trials. Int Wound J. 2021;[Epub ahead of print]. Harcup JW, Saul PA. A study of the effect of cadexomer iodine in the treatment of venous leg ulcers. Br J Clin Pract. 1986;40(9):360-364. Do not take Iodosorb (cadexomer iodine gel) by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn). Each gram of cadexomer iodine can absorb up to 6ml of fluid. When Iodosorb Cadoxemer Iodine Ointment needs changing, it changes colour for easy identification. The ointment is non-adhesive so can be easily removed without damaging the fragile tissue underneath. Directions This medicine can stain your skin and clothing. Alcohol may be used to remove iodine stain on the skin. Stains on clothing can be removed by washing and rinsing them in ammonia diluted with water. Stains on starched linens can be removed by washing them in soap and water. Side Effects of IodosorbYou may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch. The formed gel possesses chromatographic properties and acts as an inverter column. Exudate, pus and debris are removed from the wound surface into the gel matrix. The review included 13 studies comparing IODOSORB Dressings with standard care, summarising the clinical evidence supporting IODOSORB Dressings in wound bed preparation. In addition to patient comorbidities, there were a number of local factors that could act as barriers to wound healing. These included excessive exudate, cellular debris/pus/slough, and the presence of biofilm or infection. 1 Related/similar drugs Betadine, iodine topical, ethanol topical, silver nitrate topical, Betadine Aerosol Spray, Dakins Full Strength Solution Proper use of Iodosorb

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Hesler B. Release of iodine from IODOSORB/IODOFLEX Dressing into 0.9% saline solution over a three day period. Smith&Nephew Data on File # DS.18.026.R. (2018). Akiyama H, Oono T, Saito M, Iwatsuki K. Assessment of Cadexomer Iodine against Staphylococcus aureus Biofilm In vivo and In vitro Using Confocal Laset Scanning Microscopy. The Journal of Dermatology. 2004;31:529-534. Wolcott RD, Rhoads DD, Bennett ME, et al. Chronic wounds and the medical biofilm paradigm. J Wound Care. 2010;19(2):45-53. Hansson C, Persson L-M, Stenquist B, et al. The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. International Journal of Dermatology. 1998;37(390-396).

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Schierle CF, De la Garza M, Mustoe TA, Galiano RD. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair Regen. 2009;17(3):354-359.

Iodine is secreted into breast milk. Clinical experience of use in lactating women is limited. Iodosorb medicated ointment should therefore not be used in lactating women.

In endemic goitre, there have been isolated reports of hyperthyroidism associated with exogenous iodine. Hesler B. Release of iodine from IODOSORB Ointment into 0.9% saline solution over a three day period. Smith&Nephew Data on File # DS.18.025.R. (2018). In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; Oates JL, Phillips CD, Wolcott R, Woodmansey E. Effect of a Cadexomer Iodine Wound Dressing on a Chronic Wound Multi-Species Biofilm Model with Comparison to a Silver Hydrofiber Antibiofilm Dressing. Paper presented at: SAWC; 2016; Las Vegas, USA.