Treatment should be continued for at least six months before failure is concluded from the absence of a clinical response. If a patient requires a general anaesthesia, the normal Madopar regimen should be continued as close to the surgery as possible, except in the case of halothane. In general anaesthesia with halothane, Madopar should be discontinued 12 - 48 hours before surgical intervention as fluctuations in blood pressure and/or arrhythmias may occur in patients on Madopar therapy. Madopar therapy may be resumed following surgery; the dosage should be increased gradually to the preoperative level. Phenothiazines - such as chlorpromazine, promazine and prochloroperazine (used to treat mental illness). Levodopa/carbidopa is associated with somnolence and has been associated very rarely with excessive daytime somnolence and sudden sleep onset episodes.

There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant administration of tricyclic anti-depressants and carbidopa/levodopa preparations. (see section 4.3 for patients receiving mono-amine oxidase inhibitors). If general anaesthesia is required, levodopa/carbidopa may be continued as long as the patient is permitted to take oral medication. If therapy is interrupted temporarily, the usual daily dose may be administered as soon as the patient is able to take oral medication. Rare (≥1/10,000 to <1/1,000): Agitation, fear, reduced thinking capacity, disorientation, headache, increased libido, numbness and convulsions Lecado 100/25 mg is designed for use in patients, who have not previously had levodopa treatment or to aid titration in patients who receive Lecado 200/50 mg. The recommended starting dose is one tablet of Lecado 100/25 mg two times per day. In patients who need more levodopa a daily dose of three to four tablets of Lecado 100/25 mg is usually well tolerated.The mean time to reach the maximal plasma concentrations was reduced a little with Levodopa+Carbidopa 100+25 mg retard over Levodopa+Carbidopa 200+50 mg retard. In the details section, you first get a summary of the color and, if available, a description like "dark muted red". You can see the color distribution in different formats. For example, in the RGB format, you get to know the amount of red, green, and blue in your color.

Side effects that occur frequently in patients receiving levodopa/carbidopa are those due to the central neuropharmacologic activity of dopamine. These reactions usually can be diminished by dose reduction. The most common side effects are dyskinesias, including choreiform, dystonic, and other involuntary movements and nausea. Muscle twitching and blepharospasm may be taken as early signs to consider dose reduction.A symptom complex resembling the neuroleptic malignant syndrome, including muscular rigidity, increased body temperature, mental changes and increased serum creatine phosphokinase, has been reported when anti Parkinsonian medication was withdrawn abruptly. Therefore patients should be carefully observed when the dose of carbidopa/levodopa combinations is abruptly reduced or discontinued, especially if the patient is receiving anti-psychotics.

Therefore, patients and providers are advised to monitor for melanomas on a regular basis when using levodopa/carbidopa for any indication.Levodopa has been associated with somnolence and episodes of sudden sleep onset. Sudden onset of sleep during daily activities, in some cases without awareness or warning signs, has been reported very rarely. Patients must be informed of this and advised to exercise caution while driving or operating machines during treatment with levodopa. Patients who have experienced somnolence or an episode of sudden sleep onset must refrain from driving or operating machines. A reduction of dosage or termination of therapy may be considered. Feeling excited, anxious, agitated, depressed, aggressive or disorientated (the feeling of being lost). Levodopa relieves the symptoms of Parkinson's disease by being decarboxylated to dopamine in the brain. Carbidopa, which does not pass the blood/brain barrier, inhibits only the extra-cerebral decarboxylation of levodopa, making more levodopa available for transport to the brain and subsequent conversion to dopamine. Therefore it is normally not necessary to administer high doses of levodopa at frequent intervals. Gastro-intestinal and cardio-vascular side-effects, in particular those which can be attributed to the dopamine formed in the extra-cerebral tissues, are avoided totally or partially by the reduced dose.