Jade Thirlwall indulges in chips and descends into giggles while on a ride with her pals as she enjoys a trip to Winter Wonderland Two hurt after Christmas Wonderland ride 'went wrong' at Essex shopping centre - with ride forced to close

Grace Dent will be paid her FULL I'm A Celebrity fee despite quitting the show after just eight days in camp By licence dated 5 July 1502 Richard Neville married secondly, Margaret (d. 16 December 1521), the widow of Sir James Strangways.[26] She is adept at legal research to identify the best option when complex and unusual issues arise in any commercial property transaction. William Hague says the prospect of The Telegraph being owned by a UAE-based company is 'disturbing and... c) CATHERINE . m firstly OLIVER Sutton [Dudley] , son of --- (-Edgecote 1469). m secondly JAMES Radcliffe, son of ---.Five dead in wedding massacre as 'drunk' Paralympic athlete groom, 29, shoots his wife, 44, mother-in-law and guests then kills himself after arguing during the ceremony in Thailand Omid Scobie's new book is branded 'vicious' as he claims Charles, Camilla and William conspired to undermine Harry and Meghan Elizabeth Hurley, 58, shows off her jaw dropping figure in a skimpy red bikini as she relaxes in a swimming pool during Thailand getaway

Rishi Sunak's great reset stalls as new poll shows Labour extending its lead to 20 points despite... The Couple Next Door review: A steamy thriller where even putting out the bins is raunchy, writes CHRISTOPHER STEVENS

Saillot, Jacques, Cahiers de Saint-Louis (Angers: Jacques Saillot, 1976.), p. 913, Family History Library, 944 D22ds. How cooking like granny can HALVE your grocery bills! SUSANNAH JOWITT on ways to ditch food delivery apps and ready meals and feast on a diet of stews and puddings David Walliams SETTLES lawsuit with Britain's Got Talent producers after being 'forced out' of show - but... Strictly Come Dancing star Amanda Abbington shows off her dramatic hair transformation just weeks after she quit the hit BBC show S11568] The Complete Peerage of England, Scotland, Ireland, Great Britain, and the United Kingdom, by George Edward Cokayne, Vol. VII, p. 479-480.

Joely Kim Richardson was born in Marylebone, London, to the theatrical Redgrave family, the daughter of actress Vanessa Redgrave and director Tony Richardson (1928–1991), and the granddaughter of actors Sir Michael Redgrave (1908–1985) and Rachel Kempson (1910–2003), Lady Redgrave. [a] Actress Natasha Richardson (1963–2009) was her sister and actor Liam Neeson is her brother-in-law. She is the aunt of Micheál and Daniel Neeson and the niece of actors Lynn Redgrave (1943-2010) and Corin Redgrave (1939–2010) and cousin of actress Jemma Redgrave, who is five days younger than Richardson.Harry and Meghan are 'still hurt' about the delay in giving Archie and Lilibet their Prince and Princess...

N2 - Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. These include a number of clinically actionable alterations and mutations inactivating SWI-SNF and JAK2-STAT3 pathways.Tommy Fury's face is playfully squeezed by a female reveller as he parties with Chris Brown - after fiancée Molly-Mae Hague is seen without her ring I want to know if Brianna screams like a man or a girl': Teens accused of murdering transgender schoolgirl Brianna Ghey swapped messages as they plotted to lure her to a park where one of them stabbed her 28 times, murder trial hears Gareth Southgate's agent and the missing millions: England manager's cash was used without his consent to...